Endocrine Abstracts

Introduction: Fibrocalculous pancreatic diabetes is an uncommon type of diabetes mellitus due to chronic calcific non-alcoholic pancreatitis. It is associated to several particularities based on glycemic control and the occurrence of degenerative and metabolic complications, in addition to chronic pancreatitis complications.Observation: A 17-year-old male, with no familial history of diabetes and no alcohol consumption, was hospitalized in 1989 for keton...

Introduction: Graves’s disease is the most common cause of hyperthyroidism. There are three current therapeutic options: anti-thyroid medication, surgery, and radioactive iodine (I 131). There are few data in the literature regarding the effects of radioiodine therapy.Case report: We describe a 47-year-old patient who had Grave’s disease resistant to anti thyroid medication. Radioactive iodine was indicated. The patient was reluctant because sh...

Introduction: Follicular cancer has a low incidence in Graves’ disease when compared to papillary thyroid cancer. Some studies have not reported any follicular cancer in patients with Graves’ disease. We describe a rare occurrence of follicular cancer in a patient with Graves’ disease.Observation: A 37-year-old female patient presented to our institute with symptoms of thyrotoxicosis. She had no family history of thyroid cancer or of radia...

Papillary thyroid carcinoma is rare in young patients and have a good prognosis, although it is often diagnosed at the stage of lung metastases. Our multicenter study included 15 children aged between 5 and 18 years with female predominance, followed for differentiated thyroid cancer with lung metastases. All these patients underwent a whole body scan with I-131, serum thyroglobulin, chest radiography and/or cervico-thoracic CT. Scintigraphy had shown pulmonary miliary among a...

Introduction: Thyroid tuberculosis is a rare disease, its frequency is 0.15–0.2% of autopsic data. We report a case of micro papillary carcinoma of thyroid revealed by thyroid tuberculosis.Observation: Mrs. K.J aged 54 years presented a multinodular goiter without ultrasound signs of malignancy. The patient underwent total thyroidectomy. Histological examination revealed a granulomatous and giganto cellular inflammation which is in favor of a tuberc...

Introduction: TSH-secreting pituitary adenomas are rare pituitary functioning tumors accounting for <2% of the pituitary adenomas. Their association to meningiomas is a very rare condition.We report a case of 55-year-old woman who had multinodular goiter with mild symptoms of hyperthyroidism. Blood tests showed inappropriate secretion of TSH and magnetic resonance imaging (MRI) revealed a pituitary tumor with maximum diameter of 13 mm that was extirp...

Introduction: Dopamine agonist resistance is rare in prolactinoma (10%). Doses of cabergoline of up to 2.0 mg/week are usually effective in controlling prolactin (PRL) secretion and reducing tumor size. Surgical treatment is rarely indicated.Case report: An 18-year-old female presented in 2002 with a 2-year history of amenorrhea and galactorrhea. Hormonal investigation showed a hyperprolactinemia (4800 mUI/l) with integrity of the other pituitary axis. T...

Introduction: Thyroid dyshormonogenesis (TD) accounts for 15–20% of congenital hypothyroidism (CH). Levothyroxine is the treatment of choice with the immediate goal to raise the serum T4 as rapidly as possible. Surgical treatment is indicated in case of compressive or suspected goiter.Patients and methods: Seventeen patients with thyroid dyshormonogenesis belonging to 4 Tunisian families were included in a descriptive prospective study. They were fo...

Background: Although the issue of cardiovascular complications in type 2 diabetic patients is widely discussed and recommendations for such screening are known, it is less common to do so for type 1 diabetes mellitus (T1DM). Unfortunately, the mortality rate due to vascular complications is higher among type 1 diabetic patients than in the general population.Patients and methods: Seventy-six patients with T1DM history over 20 years were included in our s...

Introduction: Subclinical Cushing’s syndrome refers to autonomous cortisol secretion in patients who do not have the typical signs and symptoms of hypercortisolism. This study was undertaken to describe clinical, biological and radiological features of this disease and to evaluate the clinical outcome after surgical and medical treatment.Methods: Retrospective study conducted over a period of 12 years and including 17 patients hospitalised in our de...